Andrew Mansfield Head of Flow Chemistry, Syrris
I spotted an exciting study about a sustainable, versatile, fast and environmentally friendly CBS-asymmetric reduction of aryl and heteroaryl ketones using flow technologies. The researchers at the Department of Pharmacy (University of Bari, Italy) demonstrated handling of a borane solution safely and the switch to the use of 2-MeTHF as a greener alternative to traditional solvents. Another real benefit of using flow technology was that it allowed for a reduction of the amount of the chiral catalyst and avoided the use of an additive such as DEAN (N,N-diethylaniline). They used in-line FT-IR analysis for rapid reaction optimization and continuous aqueous work-up technologies enabled >90% recovery of the desired chloroalcohol. Study details below – happy reading! A convenient enantioselective CBS-reduction of arylketones in flow-microreactor systems Sonia De Angelis,a Maddalena De Renzo,a Claudia Carlucci,a Leonardo Degennaro*a and Renzo Luisi*a Show Affiliations Org. Biomol. Chem., 2016,14, 4304-4311 DOI: 10.1039/C6OB00336B Received 11 Feb 2016, Accepted 06 Apr 2016 First published online 06 Apr 2016
About Dr. Andrew Mansfield
Andrew was formerly a Research Chemist at Pfizer and spent much of his career focusing on introducing flow chemistry technologies, meaning Andrew is well placed to lead Syrris’ flow chemistry offering. Read Andrew’s bio here.
So why should your lab consider performing your chemistry using continuous flow chemistry techniques? Discover several reasons including faster and reactions, and accessing novel chemistries not possible in batch
With modern technology, you can automate your entire lab if you wanted to, from automated liquid handling and motorized pipettes through to robots labeling your samples. But the easiest place to start is the source of your reactions – your jacketed reactor.
When you break it down, flow chemistry is not as scary a prospect as it might seem. Photos in your favorite chemistry magazine may make it look complex, but all you really need is a pump, some tubes, and a mixing junction.
With the introduction of flow chemistry systems, chemists now have more choice available to them for performing their chemistry, and it’s important to understand whether batch or flow techniques are best for their specific applications.