Andrew Mansfield Head of Flow Chemistry, Syrris

Minute read

A convenient enantioselective CBS-reduction of arylketones in flow

By on April 20th, 2018 in Flow chemistry

I spotted an exciting study about a sustainable, versatile, fast and environmentally friendly CBS-asymmetric reduction of aryl and heteroaryl ketones using flow technologies.

The researchers at the Department of Pharmacy (University of Bari, Italy) demonstrated handling of a borane solution safely and the switch to the use of 2-MeTHF as a greener alternative to traditional solvents. Another real benefit of using flow technology was that it allowed for a reduction of the amount of the chiral catalyst and avoided the use of an additive such as DEAN (N, N-diethylaniline). They used in-line FT-IR analysis for rapid reaction optimization and continuous aqueous work-up technologies enabled >90% recovery of the desired chloroalcohol.

Study details below – happy reading!

A convenient enantioselective CBS-reduction of arylketones in flow-microreactor systems

Sonia De Angelis,a Maddalena De Renzo,a Claudia Carlucci,a Leonardo Degennaro*a and Renzo Luisi*a
Show Affiliations Org. Biomol. Chem., 2016,14, 4304-4311
DOI: 10.1039/C6OB00336B
Received 11 Feb 2016, Accepted 06 Apr 2016
First published online 06 Apr 2016

About Dr. Andrew Mansfield

Andrew was formerly a Research Chemist at Pfizer and spent much of his career focusing on introducing flow chemistry technologies, meaning Andrew is well placed to lead Syrris’ flow chemistry offering. Read Andrew’s bio here.

Related posts:

Electrochemistry made easy with continuous flow chemistry techniques

Over the past 5 years or so the development of continuous flow electrochemical cells has made selective syntheses with high reactant-to-product conversions possible. These devices offer an easy access to electrochemical techniques which is driving its current re-assessment as a viable, attractive synthetic method. Discover more in this blog post.