Andrew Mansfield Head of Flow Chemistry, Syrris
The researchers at the Department of Pharmacy (University of Bari, Italy) demonstrated handling of a borane solution safely and the switch to the use of 2-MeTHF as a greener alternative to traditional solvents. Another real benefit of using flow technology was that it allowed for a reduction of the amount of the chiral catalyst and avoided the use of an additive such as DEAN (N, N-diethylaniline). They used in-line FT-IR analysis for rapid reaction optimization and continuous aqueous work-up technologies enabled >90% recovery of the desired chloroalcohol.
Study details below – happy reading!
A convenient enantioselective CBS-reduction of arylketones in flow-microreactor systems
Sonia De Angelis,a Maddalena De Renzo,a Claudia Carlucci,a Leonardo Degennaro*a and Renzo Luisi*a
Show Affiliations Org. Biomol. Chem., 2016,14, 4304-4311
Received 11 Feb 2016, Accepted 06 Apr 2016
First published online 06 Apr 2016
About Dr. Andrew Mansfield
Andrew was formerly a Research Chemist at Pfizer and spent much of his career focusing on introducing flow chemistry technologies, meaning Andrew is well placed to lead Syrris’ flow chemistry offering. Read Andrew’s bio here.
Let’s start with the basics and explain what flow chemistry actually is and talk a bit about why it’s so useful. Flow chemistry is the process of performing chemical reactions in a tube or pipe. Read on to learn more…
So why should your lab consider performing your chemistry using continuous flow chemistry techniques? Discover several reasons including faster and reactions, and accessing novel chemistries not possible in batch
My first introduction to practical flow chemistry was as a Research Chemist at Pfizer and my first thought was: “why on earth would I want to conduct my chemistry in tiny tubes?” A few years later I was the biggest advocate for it. This blog post explains why…
Over the past 5 years or so the development of continuous flow electrochemical cells has made selective syntheses with high reactant-to-product conversions possible. These devices offer an easy access to electrochemical techniques which is driving its current re-assessment as a viable, attractive synthetic method. Discover more in this blog post.