The use of flow chemistry methods in the synthesis of chemical compounds is well documented to give a wide range of benefits over traditional batch methods. The use of reactive gases under these conditions is not so readily explored however. The use of reactive gases in research laboratories is often under used due to issues with safety concerns, the containment of pressurized gases and associated costs of scaling up these reactions.

The use of flow chemistry methods can overcome these problems, often giving cleaner reactions, increased cost efficiency and ease of work-up.

I wanted to demonstrate an easy-to-use, safe, continuous method for the introduction of reactive gases in a liquid/gas plug-flow method under anhydrous conditions.

Watch my video below to see the synthesis of a carboxylic acid from a Grignard reagent using CO2 gas directly introduced into a micro-reactor. Enjoy!